IL12RB1 antibody

Catalog No. ABIN2689092

The Rat Monoclonal anti-IL12RB1 antibody has been validated for FACS and FM. It is suitable to detect IL12RB1 in samples from Human. There are 2+ publications available.

Quick Overview for IL12RB1 antibody (ABIN2689092)

Target: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This IL12RB1 antibody is un-conjugated

Application: Flow Cytometry (FACS), Fluorescence Microscopy (FM)

Clone: 2B6-12beta2

Product Details anti-IL12RB1 Antibody

Characteristics: Reacts with IL-12Rβ2 subunit, one of two subunits of IL-12Rβ. It is expressed on T cells and NK cells. IL-12R is a glycoprotein member of the hemopoietin receptor superfamily and is related to gp130, the granulocyte-colony stimulating factor (G-CSF) receptor and leukemia inhibitory factor (LIF). Reports indicate that both, IL-12Rβ1 (CD212) and IL-12Rβ2 subunits together are capable of high affinity binding to IL-12. IL-12 is an immunomodulatory cytokine produced mainly by antigen presenting cells (APC) and plays a role in promoting Th1-type responses and cell mediated immunity. It stimulates proliferation of T cells and NK cells, enhances lytic activity of lymphokine activated (LAK) cells and CTL. Profile of CD3-stimulated peripheral blood mononuclear cells (3 days) analyzed by flow cytometry.

BD Pharmingen™ Purified Rat Anti-Human CD212 - Purified - Clone 2B6/12beta2 - Isotype Rat IgG2a, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-IL12RB1 antibody (ABIN2689092)

Presky, Minetti, Gillessen, Wilkinson, Wu, Gubler, Chizzonite, Gately: "Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 5, pp. 2174-9, (1998) (PubMed).

Wu, Warrier, Carvajal, Chua, Minetti, Chizzonite, Mongini, Stern, Gubler, Presky, Gately: "Biological function and distribution of human interleukin-12 receptor beta chain." in: European journal of immunology, Vol. 26, Issue 2, pp. 345-50, (1996) (PubMed).

Target Details for IL12RB1

Target: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Alternative Name: CD212

Background: Synonyms: IL-12 receptor subunit beta-2, Interleukin-12 receptor beta-2 chain

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation