NGFR antibody
Quick Overview for NGFR antibody (ABIN2689134)
Target
See all NGFR AntibodiesReactivity
Host
Clonality
Conjugate
Application
Clone
-
-
Brand
- BD Pharmingen™
-
Characteristics
-
Reacts with nerve growth factor receptor (NGFR), a 75 kD protein that has been found localized to neuronal axons, Schwann cells, and perineural cells of peripheral nerves. It has also been found in some epithelial, mesenchymal and lymphoid tissues. NGFR is the receptor for nerve growth factor (NGF), a polypeptide that is essential for normal development of the nervous system. NGF promotes survival and differentiation of sympathetic and sensory neurons during embryological development of peripheral neurons. NGF binds to two distinctive surface receptors, the p/140[prototrk] and p75[NGFR]. High affinity binding of NGF requires that both receptor molecules be expressed. NGFR has been found on human and rat lymphocytes. A subset of lymphoid cells in the spleen, lymph nodes, and follicular dentritic cells in germinal centers of reactive lymph nodes were found to express p75. It has been reported that NGFR interaction with its ligand, NGF, may play a role in immunoregulation. NGF may function as a B-cell growth factor. Profile of REH cell line analyzed by flow cytometry
BD Pharmingen™ Purified Mouse Anti-Human CD271 - Purified - Clone C40-1457 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg -
Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
-
Isotype
- IgG1 kappa
-
-
-
-
Application Notes
- Optimal working dilution should be determined by the investigator.
-
Restrictions
- For Research Use only
-
-
-
Concentration
- 0.5 mg/mL
-
Buffer
- Aqueous buffered solution containing ≤0.09 % sodium azide.
-
Preservative
- Sodium azide
-
Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Storage
- 4 °C
-
Storage Comment
- Store undiluted at 4°C.
-
-
-
Functional nerve growth factor receptors on human B lymphocytes. Interaction with IL-2." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 11, pp. 3492-7, (1992) (PubMed).
: "High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor." in: Nature, Vol. 350, Issue 6320, pp. 678-83, (1991) (PubMed).
: "
-
Functional nerve growth factor receptors on human B lymphocytes. Interaction with IL-2." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 11, pp. 3492-7, (1992) (PubMed).
-
- NGFR (Nerve Growth Factor Receptor (NGFR))
-
Alternative Name
- CD271
-
Background
- Synonyms: NGF Receptor
-
Pathways
- NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding
Target
-