NGFR antibody

Catalog No. ABIN2689134

The Mouse Monoclonal anti-NGFR antibody has been validated for FACS, IHC and FM. It is suitable to detect NGFR in samples from Human. There are 2+ publications available.

Quick Overview for NGFR antibody (ABIN2689134)

Target: NGFR (Nerve Growth Factor Receptor (NGFR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NGFR antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), Fluorescence Microscopy (FM)

Clone: C40

Product Details anti-NGFR Antibody

Brand: BD Pharmingen™

Characteristics: Reacts with nerve growth factor receptor (NGFR), a 75 kD protein that has been found localized to neuronal axons, Schwann cells, and perineural cells of peripheral nerves. It has also been found in some epithelial, mesenchymal and lymphoid tissues. NGFR is the receptor for nerve growth factor (NGF), a polypeptide that is essential for normal development of the nervous system. NGF promotes survival and differentiation of sympathetic and sensory neurons during embryological development of peripheral neurons. NGF binds to two distinctive surface receptors, the p/140[prototrk] and p75[NGFR]. High affinity binding of NGF requires that both receptor molecules be expressed. NGFR has been found on human and rat lymphocytes. A subset of lymphoid cells in the spleen, lymph nodes, and follicular dentritic cells in germinal centers of reactive lymph nodes were found to express p75. It has been reported that NGFR interaction with its ligand, NGF, may play a role in immunoregulation. NGF may function as a B-cell growth factor. Profile of REH cell line analyzed by flow cytometry

BD Pharmingen™ Purified Mouse Anti-Human CD271 - Purified - Clone C40-1457 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-NGFR antibody (ABIN2689134)

Brodie, Gelfand: "Functional nerve growth factor receptors on human B lymphocytes. Interaction with IL-2." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 11, pp. 3492-7, (1992) (PubMed).

Hempstead, Martin-Zanca, Kaplan, Parada, Chao: "High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor." in: Nature, Vol. 350, Issue 6320, pp. 678-83, (1991) (PubMed).

Target Details for NGFR

Target: NGFR (Nerve Growth Factor Receptor (NGFR))

Alternative Name: CD271

Background: Synonyms: NGF Receptor

Pathways: NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding