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NGFR antibody

The Mouse Monoclonal anti-NGFR antibody has been validated for FACS, IHC and FM. It is suitable to detect NGFR in samples from Human. There are 2+ publications available.
Catalog No. ABIN2689134

Quick Overview for NGFR antibody (ABIN2689134)

Target

See all NGFR Antibodies
NGFR (Nerve Growth Factor Receptor (NGFR))

Reactivity

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Human

Host

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Mouse

Clonality

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Monoclonal

Conjugate

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This NGFR antibody is un-conjugated

Application

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Flow Cytometry (FACS), Immunohistochemistry (IHC), Fluorescence Microscopy (FM)

Clone

C40
  • Brand

    BD Pharmingen™

    Characteristics

    Reacts with nerve growth factor receptor (NGFR), a 75 kD protein that has been found localized to neuronal axons, Schwann cells, and perineural cells of peripheral nerves. It has also been found in some epithelial, mesenchymal and lymphoid tissues. NGFR is the receptor for nerve growth factor (NGF), a polypeptide that is essential for normal development of the nervous system. NGF promotes survival and differentiation of sympathetic and sensory neurons during embryological development of peripheral neurons. NGF binds to two distinctive surface receptors, the p/140[prototrk] and p75[NGFR]. High affinity binding of NGF requires that both receptor molecules be expressed. NGFR has been found on human and rat lymphocytes. A subset of lymphoid cells in the spleen, lymph nodes, and follicular dentritic cells in germinal centers of reactive lymph nodes were found to express p75. It has been reported that NGFR interaction with its ligand, NGF, may play a role in immunoregulation. NGF may function as a B-cell growth factor. Profile of REH cell line analyzed by flow cytometry

    BD Pharmingen™ Purified Mouse Anti-Human CD271 - Purified - Clone C40-1457 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

    Purification

    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

    Isotype

    IgG1 kappa
  • Application Notes

    Optimal working dilution should be determined by the investigator.

    Restrictions

    For Research Use only
  • Concentration

    0.5 mg/mL

    Buffer

    Aqueous buffered solution containing ≤0.09 % sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C

    Storage Comment

    Store undiluted at 4°C.
  • Brodie, Gelfand: "Functional nerve growth factor receptors on human B lymphocytes. Interaction with IL-2." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 11, pp. 3492-7, (1992) (PubMed).

    Hempstead, Martin-Zanca, Kaplan, Parada, Chao: "High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor." in: Nature, Vol. 350, Issue 6320, pp. 678-83, (1991) (PubMed).

  • Target

    NGFR (Nerve Growth Factor Receptor (NGFR))

    Alternative Name

    CD271

    Background

    Synonyms: NGF Receptor

    Pathways

    NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding
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