Interleukin 17a antibody (Biotin)

Catalog No. ABIN2689740

There are 4+ publications for this product available. The Rat Monoclonal anti-Interleukin 17a antibody is suitable to detect Interleukin 17a in samples from Mouse. It has been validated for ELISA and WB.

Quick Overview for Interleukin 17a antibody (Biotin) (ABIN2689740)

Target: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This Interleukin 17a antibody is conjugated to Biotin

Application: ELISA, Western Blotting (WB)

Clone: TC11

Product Details anti-Interleukin 17a Antibody (Biotin)

Characteristics: The TC11-8H4 monoclonal antibody specifically binds to recombinant and natural mouse IL-17A proteins. IL-17A, also known as Cytotoxic T-lymphocyte-associated antigen 8 (CTLA-8), is a T cell-derived cytokine that promotes inflammatory responses. Mouse IL-17A is a proinflammatory cytokine that can induce the release of IL-6 by mouse stromal cells. It has been shown to support the growth of hemopoietic progenitors in vitro, it can also stimulate granulopoiesis in vivo. Recent studies have shown that IL-17A is produced by a unique subset of Th17 cells that develop along a pathway distinct from the Th1- and Th2- cell differentiation pathways. The mouse IL-17A cDNA was isolated from a cDNA library generated from TCRαβ+CD4-CD8- thymocytes. Standard Curve Mouse IL-17A

BD Pharmingen™ Biotin Rat Anti-Mouse IL-17A - Biotin - Clone TC11-8H4 - Isotype Rat IgG1, κ - Reactivity Ms - 0.5 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Recombinant mouse IL-17A

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

References for anti-Interleukin 17a antibody (Biotin) (ABIN2689740)

Dong: "Mouse Th17 cells: current understanding of their generation and regulation." in: European journal of immunology, Vol. 39, Issue 3, pp. 640-4, (2009) (PubMed).

Coquet, Chakravarti, Kyparissoudis, McNab, Pitt, McKenzie, Berzins, Smyth, Godfrey: "Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 32, pp. 11287-92, (2008) (PubMed).

Lampropoulou, Hoehlig, Roch, Neves, Calderón Gómez, Sweenie, Hao, Freitas, Steinhoff, Anderton, Fillatreau: "TLR-activated B cells suppress T cell-mediated autoimmunity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 7, pp. 4763-73, (2008) (PubMed).

Schwarzenberger, La Russa, Miller, Ye, Huang, Zieske, Nelson, Bagby, Stoltz, Mynatt, Spriggs, Kolls: "IL-17 stimulates granulopoiesis in mice: use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 11, pp. 6383-9, (1998) (PubMed).

Target Details for Interleukin 17a

Target: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Alternative Name: IL-17A

Background: Synonyms: IL-17, Il17, IL-17A, Il17a, CTLA-8, Ctla8, Interleukin-17A, interleukin 17A