Catalase antibody

Catalog No. ABIN2717106

The Mouse Monoclonal anti-Catalase antibody has been validated for WB, IHC and IF. It is suitable to detect Catalase in samples from Human, Rat, Dog and Monkey. There is 1 publication available.

Quick Overview for Catalase antibody (ABIN2717106)

Target: Catalase (CAT)

Reactivity: Human, Rat, Dog, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This Catalase antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: 1B6

Product Details anti-Catalase Antibody

Characteristics: Homo sapiens catalase (CAT)

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Full length human recombinant protein of human CAT (NP_111743) produced in HEK293T cell.

Isotype: IgG1

Application Details

Application Notes: WB 1:200~500, IHC 1:150, IF 1:100,

Comment:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-Catalase antibody (ABIN2717106)

Benlloch, Obrador, Valles, Rodriguez, Sirerol, Alcácer, Pellicer, Salvador, Cerdá, Sáez, Estrela: "Pterostilbene Decreases the Antioxidant Defenses of Aggressive Cancer Cells In Vivo: A Physiological Glucocorticoids- and Nrf2-Dependent Mechanism." in: Antioxidants & redox signaling, Vol. 24, Issue 17, pp. 974-90, (2016) (PubMed).

Target Details for Catalase

Target: Catalase (CAT)

Alternative Name: CAT

Background: This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene.

Molecular Weight: 59.6 kDa

Gene ID: 847

NCBI Accession: NM_001752

HGNC: 847

Pathways: Cellular Glucan Metabolic Process, Cell RedoxHomeostasis, Photoperiodism