CCM2 antibody

Catalog No. ABIN2725241

The Mouse Monoclonal anti-CCM2 antibody (Clone 2E4) (ABIN2725241) specifically detects CCM2 in WB, IF and IHC. The antibody is reactive with Human samples.

Quick Overview for CCM2 antibody (ABIN2725241)

Target: CCM2 (Cerebral Cavernous Malformation 2 (CCM2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CCM2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Clone: 2E4

Product Details anti-CCM2 Antibody

Characteristics: Homo sapiens cerebral cavernous malformation 2 (CCM2), transcript variant 2

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Full length human recombinant protein of human CCM2(NP_113631) produced in HEK293T cell.

Isotype: IgG1

Application Details

Application Notes: WB 1:2000, IHC 1:150, IF 1:100,

Comment:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for CCM2

Target: CCM2 (Cerebral Cavernous Malformation 2 (CCM2))

Alternative Name: CCM2

Background: This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 48.7 kDa

Gene ID: 83605

NCBI Accession: NM_031443

HGNC: 83605

Pathways: Cell-Cell Junction Organization