MYD88 antibody

Catalog No. ABIN2726635

Product Details anti-MYD88 Antibody

Target: MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MYD88 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Characteristics: Homo sapiens myeloid differentiation primary response gene (88) (MYD88), transcript variant 2

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Full length human recombinant protein of human MYD88 (NP_002459) produced in HEK293T cell.

Clone: 2B2

Isotype: IgG2a

Application Details

Application Notes: WB 1:2000, IHC 1:150, IF 1:100, FLOW 1:100

Comment:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-MYD88 antibody (ABIN2726635)

Mendez, Banerjee: "Proximal Ligation Assay (PLA) on Lung Tissue and Cultured Macrophages to Demonstrate Protein-protein Interaction." in: Bio-protocol, Vol. 7, Issue 21, (2017) (PubMed).

Caner, Sen Turk, Baris, Cetin, Tepeli, Hacioglu, Sari, Zencir, Dogu, Bagci, Keskin: "MYD88 Expression and L265P Mutation in Mature B-Cell Non-Hodgkin Lymphomas." in: Genetic testing and molecular biomarkers, Vol. 19, Issue 7, pp. 372-8, (2015) (PubMed).

Choi, Kim, Lee, Kim: "MYD88 expression and L265P mutation in diffuse large B-cell lymphoma." in: Human pathology, (2013) (PubMed).

Target Details for MYD88

Target: MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))

Alternative Name: MYD88 (MYD88 Products)

Background: This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.

Molecular Weight: 33.1 kDa

Gene ID: 4615

NCBI Accession: NM_002468

HGNC: 4615

Pathways: NF-kappaB Signaling, TLR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades