Cytokeratin 19 antibody (AA 379-392)

Catalog No. ABIN2742480

This anti-Cytokeratin 19 antibody is a Rabbit Polyclonal antibody detecting Cytokeratin 19 in WB, IHC, IHC (p), ICC and IHC (fro). Suitable for Human.

Quick Overview for Cytokeratin 19 antibody (AA 379-392) (ABIN2742480)

Target: Cytokeratin 19 (KRT19) (Keratin 19 (KRT19))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cytokeratin 19 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Cytokeratin 19 Antibody

Binding Specificity: AA 379-392

Specificity: Human KRT19 / CK19 / Cytokeratin 19

Purification: Immunoaffinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Cytokeratin 19 (379-392aa YRSLLEGQEDHYNN). Percent identity by BLAST analysis: Human, Gorilla, Monkey (100%), Orangutan, Marmoset, Mouse (93%), Baboon, Rat, Rabbit (86%).

Type of Immunogen: Synthetic peptide

Isotype: IgG

Application Details

Application Notes: Approved: ICC (0.5 - 1 μg/mL), IHC, IHC-Fr (0.5 - 1 μg/mL), IHC-P (0.5 - 1 μg/mL), WB (0.5 - 1 μg/mL)

Usage: Keratin, type I cytoskeletal 19 is a protein that in humans is encoded by the KRT19 gene.The protein encoded by this gene is a member of the keratin family. It is specifically expressed in the periderm, the transiently superficial layer that envelops the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. Due to its high sensitivity, KRT19 is the most used marker for the RT-PCR-mediated detection of tumor cells disseminated in lymph nodes, peripheral blood, and bone marrow of breast cancer patients. Keratin 19 is often used together with keratin 8 and keratin 18 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Sterile distilled water

Concentration: Lot specific

Buffer: Lyophilized from PBS, 2.5 % BSA, 0.025 % sodium azide/thimerosal.

Preservative: Sodium azide, Thimerosal (Merthiolate)

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for 1 month or -20°C for longer. Avoid freeze/thaw cycles.

Target Details for Cytokeratin 19

Target: Cytokeratin 19 (KRT19) (Keratin 19 (KRT19))

Alternative Name: KRT19 / CK19 / Cytokeratin 19

Background: Name/Gene ID: KRT19

Synonyms: KRT19, CK19, Cytokeratin 19, Cytokeratin-19, Keratin 19, Keratin-19, CK-19, K19, K1CS, Keratin, type I, 40-kd

Gene ID: 3880