TIMP3 antibody (AA 198-211)

Catalog No. ABIN2744876

The Rabbit Polyclonal anti-TIMP3 antibody has been validated for WB and ELISA. It is suitable to detect TIMP3 in samples from Human, Rat, Cow, Dog, Pig, Sheep, Monkey, Chimpanzee and Gibbon.

Quick Overview for TIMP3 antibody (AA 198-211) (ABIN2744876)

Target: TIMP3 (TIMP Metallopeptidase Inhibitor 3 (TIMP3))

Reactivity: Human, Rat, Cow, Dog, Pig, Sheep, Monkey, Chimpanzee, Gibbon

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIMP3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TIMP3 Antibody

Binding Specificity: AA 198-211

Specificity: Human TIMP3

Purification: Immunoaffinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human TIMP3(198-211aa WAPPDKSIINATDP). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset, Ferret, Sheep, Cat, Bovine, Pig, Dog (100%), Mouse, Bat, Hamster, Opossum, Zebra finch, Chicken, Lizard (93%).

Type of Immunogen: Synthetic peptide

Isotype: IgG

Application Details

Application Notes: Approved: ELISA (0.1 - 0.5 μg/mL), WB (0.5 - 1 μg/mL)

Usage: The tissue inhibitors of metalloproteinases(TIMPs) are natural inhibitors of the matrix metalloproteinases, a group of zinc-binding endopeptidases involved in the degradation of the extracellular matrix. The TIMP3 gene is expressed in many tissues, with highest expression in the placenta. TIMP3 encodes a potent angiogenesis inhibitor and is mutated in Sorsby fundus dystrophy, a macular degenerative disease with submacular choroidal neovascularization. TIMP3 gene is mapped to 22q12.1-q13.2. Mutations in TIMP3 cause the autosomal dominant disorder Sorsby's fundus dystrophy(SFD).

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Sterile distilled water

Concentration: Lot specific

Buffer: Lyophilized from PBS, 2.5 % BSA, 0.025 % sodium azide/thimerosal.

Preservative: Sodium azide, Thimerosal (Merthiolate)

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for 1 month or -20°C for longer. Avoid freeze/thaw cycles.

Target Details for TIMP3

Target: TIMP3 (TIMP Metallopeptidase Inhibitor 3 (TIMP3))

Alternative Name: TIMP3

Background: Name/Gene ID: TIMP3

Synonyms: TIMP3, HSMRK222, K222TA2, MIG-5 protein, K222, SFD, Metalloproteinase inhibitor 3, Protein MIG-5, TIMP-3

Gene ID: 7078