AZGP1 antibody

Catalog No. ABIN2745583

Product Details anti-AZGP1 Antibody

Target: AZGP1 (alpha-2-Glycoprotein 1, Zinc-Binding (AZGP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This AZGP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: Recognizes human zinc-alpha-2-glycoprotein.

Cross-Reactivity: Human

Purity: >95 % (SDS-PAGE)

Immunogen: Recombinant human zinc-alpha-2-glycoprotein.

Clone: Zagy-1

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

Target Details for AZGP1

Target: AZGP1 (alpha-2-Glycoprotein 1, Zinc-Binding (AZGP1))

Alternative Name: ZAG (AZGP1 Products)

Synonyms: Zag antibody, ZA2G antibody, ZAG antibody, ZA2GA antibody, Zna2gp antibody, alpha-2-glycoprotein 1, zinc antibody, alpha-2-glycoprotein 1, zinc-binding antibody, Azgp1 antibody, AZGP1 antibody

Background: Zinc-alpha-2-glycoprotein (ZAG), first identified in the 1960s, derives its name from its precipitation from human plasma upon the addition of zinc salts. ZAG has since been found in secretory epithelial cells and in a range of body fluids. ZAG is identical to a lipid mobilizing factor isolated from the urine of patients with cancer cachexia and stimulates lipolysis in in vivo experiments. Due to its expression in and secretion from adipocytes, ZAG is considered an adipokine. Recently the clinical significance of ZAG has been clarified. ZAG expression in adipocytes is inversely related to fat mass, thus it is intimately involved in the maintenance of body weight in mice and humans. Epidemiological studies have uncovered an association between ZAG and plasma cholesterol. The non-synonymous single nucleotide polymorphism rs4215 in ZAG is associated with plasma cholesterol and obesity. Structurally ZAG possesses a class I major histocompatibility complex (MHC) protein fold. It is distinct from other members of this protein family in that it is soluble, rather than being anchored to plasma membranes and it associates with prolactin inducible protein rather than beta2-microglobulin. Similar to peptide antigen-presenting class I MHC molecules, ZAG possesses an open apical groove between its alpha1 and alpha2 domain helices.

UniProt: P25311

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process