EPH Receptor A6 antibody (AA 800-900)

Catalog No. ABIN2746572

The Rabbit Polyclonal anti-EPH Receptor A6 antibody has been validated for ELISA and WB. It is suitable to detect EPH Receptor A6 in samples from Human, Mouse and Rat.

Quick Overview for EPH Receptor A6 antibody (AA 800-900) (ABIN2746572)

Target: EPH Receptor A6 (Epha6)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor A6 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-EPH Receptor A6 Antibody

Binding Specificity: AA 800-900

Specificity: The antibody labels a strong band of EphAR6 at 136 kDa in ABIN1741645 samples and in other cancer cell lines.

Cross-Reactivity: Mouse (Murine), Rat (Rattus), Monkey

Cross-Reactivity (Details): Does not cross react to any other cellular protein.

Characteristics: EphAR6 selective antibodies were generated against a peptide taken from the human protein. The EphAR6-selective antibodies are affinity purified on an immobilized antigen based affinity matrix, the isolated antibodies were then stabilized in antibody stabilization buffer for long-term storage. The EphAR6- selective antibodies are fully characterized for applications in western blotting and ELISA at the recommended dilutions. The supplier provides EphA6 Western blot positive control samples in ready-to-use SDS-PAGE sample buffer. Limited quantities of antigenic blocking peptide for EphAR6 antibody is also available, please inquire before ordering.

Purification: Affinity Purified

Immunogen: Synthetic peptide taken within amino acid region 800-900 on human EphA R6 protein.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.55-0.75 μg/μL

Handling Advice: Working solutions of antibodies in buffer should be filtered through 0.45 μm filter after every use for long-term storage.

Storage: -20 °C

Storage Comment: For long-term storage of keep at -20 °C. We don't recommend storage of very dilute antibody solutions unless they are prepared in specially formulated multi use antibody dilution buffer.

Target Details for EPH Receptor A6

Target: EPH Receptor A6 (Epha6)

Alternative Name: Eprhin Receptor A6

Background: Ephrin A6, a member of the ephrin family, elicits biological responses in retinal neurons. It binds with high affinity to several other EphA receptors and causes growth cone collapse in retinal explants. Ephrin-A6 expression is high at embryonic day 6 (E6) and at embryonic day 8 (E8), when retinal axons grow to their tectal targets, and then this Ephrin-A6 expression gradually declines at later developmental stages. This new ephrin plays a role in the establishment of visual system topography as observed by the asymmetric distribution of ephrin-A6 in retinal cells. High levels of expression of Eph-A6 in the macula of developing human retina showed localization of Eph-A6 to (GC) ganglion cells. Eph receptors and Ephrins have indeed been implicated in multiple aspects of synaptic function, including clustering and modulating N-methyl-D-aspartate receptors, modifying the geometry of postsynaptic terminals, and influencing long-term synaptic plasticity and memory. Eph A6, in line with a number of other Eph receptors and their ephrin ligands, is involved in neural circuits of learning and memory. Genetic inhibition of the ephrin receptor (Eph A6) in knockout mice produced behavioral deficits in tests of learning and memory. The gene for EphAR6 is present on chromosome 3q11.2

NCBI Accession: NP_001073917

UniProt: B3KS12

Pathways: RTK Signaling