PDE2A antibody (C-Term)

Catalog No. ABIN2747086

Product Details anti-PDE2A Antibody

Target: PDE2A (phosphodiesterase 2A, CGMP-Stimulated (PDE2A))

Binding Specificity: AA 875-925, C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE2A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Confocal Microscopy (CM), Immunocytochemistry (ICC), Fluorescence Resonance Energy Transfer Microscopy (FRET)

Purification: Affinity Purified

Immunogen: Synthetic peptide taken within amino acid region 875-925 on human PDE2A protein. Will label all PD2A variants.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.7 μg/μL

References for anti-PDE2A antibody (ABIN2747086)

Fields, Koschinski, Zaccolo: "Sustained exposure to catecholamines affects cAMP/PKA compartmentalised signalling in adult rat ventricular myocytes." in: Cellular signalling, Vol. 28, Issue 7, pp. 725-32, (2017) (PubMed).

Pathak, Agostino, Bishara, Capell, Fisher, Hegde, Ibrahim, Pilarzyk, Sabin, Tuczkewycz, Wilson, Kelly: "PDE11A negatively regulates lithium responsivity." in: Molecular psychiatry, Vol. 22, Issue 12, pp. 1714-1724, (2017) (PubMed).

Vettel, Lindner, Dewenter, Lorenz, Schanbacher, Riedel, Lämmle, Meinecke, Mason, Sossalla, Geerts, Hoffmann, Wunder, Brunner, Wieland, Mehel, Karam, Lechêne, Leroy, Vandecasteele, Wagner et al.: "Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction." in: Circulation research, Vol. 120, Issue 1, pp. 120-132, (2017) (PubMed).

Sprenger, Perera, Steinbrecher, Lehnart, Maier, Hasenfuss, Nikolaev: "In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease." in: Nature communications, Vol. 6, pp. 6965, (2016) (PubMed).

Hiramoto, Murata, Shimizu, Morita, Inui, Manganiello, Tagawa, Arai: "Role of phosphodiesterase 2 in growth and invasion of human malignant melanoma cells." in: Cellular signalling, Vol. 26, Issue 9, pp. 1807-17, (2015) (PubMed).

Rentsendorj, DAlessio, Pearse: "Phosphodiesterase 2A is a major negative regulator of iNOS expression in lipopolysaccharide-treated mouse alveolar macrophages." in: Journal of leukocyte biology, Vol. 96, Issue 5, pp. 907-15, (2015) (PubMed).

Rajagopal, Nalli, Kumar, Bhattacharya, Hu, Mahavadi, Grider, Murthy: "Cytokine-induced S-nitrosylation of soluble guanylyl cyclase and expression of phosphodiesterase 1A contribute to dysfunction of longitudinal smooth muscle relaxation." in: The Journal of pharmacology and experimental therapeutics, Vol. 352, Issue 3, pp. 509-18, (2015) (PubMed).

Petersen, Kristensen, Jeppesen, Grøndahl, Wissing, Macklon, Andersen: "Distribution and function of 3',5'-Cyclic-AMP phosphodiesterases in the human ovary." in: Molecular and cellular endocrinology, Vol. 403, pp. 10-20, (2015) (PubMed).

Kedia, Ückert, Oelke, Sonnenberg, Sohn, Kuczyk, Hedlund: "Expression and distribution of phosphodiesterase isoenzymes in the human male urethra." in: Urology, Vol. 85, Issue 4, pp. 964.e1-6, (2015) (PubMed).

Zhai, Chang, Wei, Liu, Leblais, Fischmeister, Ji: "Phosphodiesterase types 3 and 4 regulate the phasic contraction of neonatal rat bladder smooth myocytes via distinct mechanisms." in: Cellular signalling, Vol. 26, Issue 5, pp. 1001-10, (2014) (PubMed).

Yougbaré, Keravis, Abusnina, Decossas, Schall, Muller, Lugnier: "Cyclic GMP catabolism up-regulation in MRL/lpr lupus-prone mice is associated with organ remodeling." in: Biochimica et biophysica acta, Vol. 1842, Issue 7, pp. 916-26, (2014) (PubMed).

Stephenson, Coskran, Kelly, Kleiman, Morton, ONeill, Schmidt, Weinberg, Menniti: "The distribution of phosphodiesterase 2A in the rat brain." in: Neuroscience, Vol. 226, pp. 145-55, (2013) (PubMed).

Ückert, Oelke, Albrecht, Breitmeier, Kuczyk, Hedlund: "Expression and distribution of key enzymes of the cyclic GMP signaling in the human clitoris: relation to phosphodiesterase type 5 (PDE5)." in: International journal of impotence research, Vol. 23, Issue 5, pp. 206-12, (2012) (PubMed).

Matsuo, Rossier, Kan, Rodriguez: "The wiring of Grueneberg ganglion axons is dependent on neuropilin 1." in: Development (Cambridge, England), Vol. 139, Issue 15, pp. 2783-91, (2012) (PubMed).

Lin, Fretier, Jiang, Vincent: "Nitric oxide signaling via cGMP-stimulated phosphodiesterase in striatal neurons." in: Synapse (New York, N.Y.), Vol. 64, Issue 6, pp. 460-6, (2010) (PubMed).

van der Horst, Morgan, Eaton, Reiss, Tibboel, Thébaud: "Expression and function of phosphodiesterases in nitrofen-induced congenital diaphragmatic hernia in rats." in: Pediatric pulmonology, Vol. 45, Issue 4, pp. 320-5, (2010) (PubMed).

Witzenrath, Gutbier, Schmeck, Tenor, Seybold, Kuelzer, Grentzmann, Hatzelmann, van Laak, Tschernig, Mitchell, Schudt, Rosseau, Suttorp, Schütte: "Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia." in: Critical care medicine, Vol. 37, Issue 2, pp. 584-90, (2009) (PubMed).

Spiessberger, Bernhard, Herrmann, Feil, Werner, Luppa, Hofmann: "cGMP-dependent protein kinase II and aldosterone secretion." in: The FEBS journal, Vol. 276, Issue 4, pp. 1007-13, (2009) (PubMed).

Liu, Fraser, Koos: "Grueneberg ganglion olfactory subsystem employs a cGMP signaling pathway." in: The Journal of comparative neurology, Vol. 516, Issue 1, pp. 36-48, (2009) (PubMed).

Walz, Feinstein, Khan, Mombaerts: "Axonal wiring of guanylate cyclase-D-expressing olfactory neurons is dependent on neuropilin 2 and semaphorin 3F." in: Development (Cambridge, England), Vol. 134, Issue 22, pp. 4063-72, (2008) (PubMed).

Target Details for PDE2A

Target: PDE2A (phosphodiesterase 2A, CGMP-Stimulated (PDE2A))

Alternative Name: PDE2A (PDE2A Products)

Pathways: cAMP Metabolic Process, Synaptic Membrane