PDE4D PKA Site (AA 50-100), (N-Term), (phosphorylated) antibody

Catalog No. ABIN2747156

This Rabbit Polyclonal antibody specifically detects PDE4D PKA Site in ELISA, IHC (p), IP and WB. It exhibits reactivity toward Human, Mouse and Rat. It has been mentioned in 4+ publications

Quick Overview for PDE4D PKA Site (AA 50-100), (N-Term), (phosphorylated) antibody (ABIN2747156)

Target: PDE4D PKA Site

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)

Product Details

Binding Specificity: AA 50-100, N-Term, phosphorylated

Purification: Affinity Purified

Immunogen: Phosphorylated synthetic peptide selective for PDE4D PKA site taken within amino acid region 50-100 on human PDE4D8 protein.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.57 μg/μL

References

Fu, Kim, Soto, De Arcangelis, DiPilato, Liu, Xu, Shi, Zhang, Xiang: "A long lasting β1 adrenergic receptor stimulation of cAMP/protein kinase A (PKA) signal in cardiac myocytes." in: The Journal of biological chemistry, Vol. 289, Issue 21, pp. 14771-81, (2014) (PubMed).

Mahavadi, Nalli, Kumar, Hu, Kuemmerle, Grider, Murthy: "Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle." in: American journal of physiology. Cell physiology, Vol. 307, Issue 4, pp. C402-11, (2014) (PubMed).

Murthy, Sriwai: "Stimulatory phosphorylation of cAMP-specific PDE4D5 by contractile agonists is mediated by PKC-dependent inactivation of protein phosphatase 2A." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 294, Issue 1, pp. G327-35, (2008) (PubMed).

Zhu, Kelly, Vemavarapu, Thompson, Strada: "Activation and induction of cyclic AMP phosphodiesterase (PDE4) in rat pulmonary microvascular endothelial cells." in: Biochemical pharmacology, Vol. 68, Issue 3, pp. 479-91, (2004) (PubMed).

Target Details

Target: PDE4D PKA Site

UniProt: Q08499