CD2 antibody

Catalog No. ABIN2749021

This anti-CD2 antibody is a Mouse Monoclonal antibody detecting CD2 in FACS and Func. Suitable for Human. This Primary Antibody has been cited in 1 publication.

Quick Overview for CD2 antibody (ABIN2749021)

Target: CD2

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD2 antibody is un-conjugated

Application: Flow Cytometry (FACS), Functional Studies (Func)

Clone: TS1-8

Product Details anti-CD2 Antibody

Purpose: Anti-Hu CD2 Purified Low Endotoxin

Specificity: The mouse monoclonal antibody TS1/8 recognizes an extracellular epitope of CD2, a 50 kDa glycoprotein present on the human peripheral blood T lymphocytes and NK cells, also expressed by all thymocytes.

Cross-Reactivity (Details): Human

Purification: Purified by protein-A affinity chromatography.

Purity: > 95 % (by SDS-PAGE)

Endotoxin Level: Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

Immunogen: Cytotoxic T lymphocytes

Isotype: IgG1 kappa

Application Details

Application Notes: Functional application: Blocking.
Flow cytometry: Recommended dilution: 1-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

References for anti-CD2 antibody (ABIN2749021)

Zhang, Dai, Li, Zhuang: "Tracking proliferative history in lymphocyte development with cre-mediated sister chromatid recombination." in: PLoS genetics, Vol. 9, Issue 10, pp. e1003887, (2013) (PubMed).

Target Details for CD2

Target: CD2

Alternative Name: CD2

Background: CD2 Molecule,CD2 belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.,T11, LFA-2, SRBC

Gene ID: 914

UniProt: P06729