NR2F6 antibody
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- Target See all NR2F6 Antibodies
- NR2F6 (Nuclear Receptor Subfamily 2, Group F, Member 6 (NR2F6))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This NR2F6 antibody is un-conjugated
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Application
- Western Blotting (WB), Flow Cytometry (FACS)
- Specificity
- The mouse monoclonal antibody EM-51 recognizes NR2F6, a transcriptional repressor (intracellular antigen) expressed mainly in the heart, placenta, liver, skeletal muscle, kidney and pancreas, but also e.g. in T cell subpopulations.
- Cross-Reactivity (Details)
- Human
- Purification
- Purified by protein-A affinity chromatography.
- Purity
- > 95 % (by SDS-PAGE)
- Immunogen
- Recombinant human NR2F6 protein expressed in E. coli
- Clone
- EM-51
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product NR2F6 Primary Antibody
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- Application Notes
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Western blotting: Positive control: HEK293T/17/NR2F6/Ha-tag transfectants, negative control: HEK293T/17 cells.
Flow cytometry: Recommended dilution: 3-9 μg/mL. Intracellular staining. - Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store at 2-8°C. Do not freeze.
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- Target
- NR2F6 (Nuclear Receptor Subfamily 2, Group F, Member 6 (NR2F6))
- Alternative Name
- NR2F6 (NR2F6 Products)
- Background
- Nuclear receptor subfamily 2 group F member 6,NR2F6 (nuclear receptor subfamily 2 group F member 6), also known as EAR2 or ERBAL2, is a transcription factor involved in modulation of hormonal responses. NR2F6 represses e.g. transcription of the oxytocin-neurophysin gene, renin gene, lutropin-choriogonadotropic hormone receptor gene, and the thyroid hormone receptor gene. In the immune system, NR2F6 affects IL-17 expression in the Th-17 cells, thus also the balance between immunological tolerance and autoimmunity.,EAR2, EAR-2, ERBAL2
- Gene ID
- 2063
- UniProt
- P10588
- Pathways
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Photoperiodism
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