NR2F6 antibody

Catalog No. ABIN2749193

This Mouse Monoclonal antibody specifically detects NR2F6 in WB and ICFC. It exhibits reactivity toward Human.

Quick Overview for NR2F6 antibody (ABIN2749193)

Target: NR2F6 (Nuclear Receptor Subfamily 2, Group F, Member 6 (NR2F6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NR2F6 antibody is un-conjugated

Application: Western Blotting (WB), Intracellular Flow Cytometry (ICFC)

Clone: EM-51

Product Details anti-NR2F6 Antibody

Purpose: Anti-NR2F6 Purified

Specificity: The mouse monoclonal antibody EM-51 recognizes NR2F6, a transcriptional repressor (intracellular antigen) expressed mainly in the heart, placenta, liver, skeletal muscle, kidney and pancreas, but also e.g. in T cell subpopulations.

Cross-Reactivity (Details): Human

Purification: Purified by protein-A affinity chromatography.

Purity: > 95 % (by SDS-PAGE)

Immunogen: Recombinant human NR2F6 protein expressed in E. coli

Isotype: IgG2a kappa

Application Details

Application Notes: Western blotting: Positive control: HEK293T/17/NR2F6/Ha-tag transfectants, negative control: HEK293T/17 cells.
Flow cytometry: Recommended dilution: 3-9 μg/mL. Intracellular staining.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for NR2F6

Target: NR2F6 (Nuclear Receptor Subfamily 2, Group F, Member 6 (NR2F6))

Alternative Name: NR2F6

Background: Nuclear receptor subfamily 2 group F member 6,NR2F6 (nuclear receptor subfamily 2 group F member 6), also known as EAR2 or ERBAL2, is a transcription factor involved in modulation of hormonal responses. NR2F6 represses e.g. transcription of the oxytocin-neurophysin gene, renin gene, lutropin-choriogonadotropic hormone receptor gene, and the thyroid hormone receptor gene. In the immune system, NR2F6 affects IL-17 expression in the Th-17 cells, thus also the balance between immunological tolerance and autoimmunity.,EAR2, EAR-2, ERBAL2

Gene ID: 2063

UniProt: P10588

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Photoperiodism