C4B antibody (AA 1454-1744) (FITC)

Catalog No. ABIN2754540

This Rabbit Polyclonal antibody specifically detects C4B in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for C4B antibody (AA 1454-1744) (FITC) (ABIN2754540)

Target: C4B (C4b) (Complement Component C4b (C4b))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C4B antibody is conjugated to FITC

Application: Western Blotting (WB), ELISA

Product Details anti-C4B Antibody (FITC)

Binding Specificity: AA 1454-1744

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Complement C4-B protein (1454-1744AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for C4B

Target: C4B (C4b) (Complement Component C4b (C4b))

Alternative Name: C4B

Background:

Background: Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Ref.16 Ref.17 Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

Aliases: Basic complement C4 antibody, C2B5 antibody, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3 antibody, C4b antibody, C4B1 antibody, C4B2 antibody, C4B3 antibody, CO4B_HUMAN antibody, Complement C4 gamma chain antibody, Complement component 4B antibody, CPAMD3 antibody

UniProt: P0C0L5

Pathways: Complement System