C4B antibody (AA 655-684)

Catalog No. ABIN657906

The Rabbit Polyclonal anti-C4B antibody (Clone RB33642) (ABIN657906) specifically detects C4B in WB. The antibody is reactive with Human samples.

Quick Overview for C4B antibody (AA 655-684) (ABIN657906)

Target: C4B (C4b) (Complement Component C4b (C4b))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C4B antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB33642

Product Details anti-C4B Antibody

Binding Specificity: AA 655-684

Predicted Reactivity: H

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This C4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 655-684 amino acids from the Central region of human C4B.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: C4B Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

Target Details for C4B

Target: C4B (C4b) (Complement Component C4b (C4b))

Alternative Name: C4B

Background: This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9.

Molecular Weight: 192785

Gene ID: 721

NCBI Accession: NP_001002029, NP_001239133, NP_009224

UniProt: P0C0L4

Pathways: Complement System