Influenza Nucleoprotein antibody (Influenza A Virus) (Biotin)

Catalog No. ABIN2754717

This Rabbit Polyclonal antibody specifically detects in ELISA and WB. It exhibits reactivity toward Influenza A Virus.

Quick Overview for Influenza Nucleoprotein antibody (Influenza A Virus) (Biotin) (ABIN2754717)

Target: Influenza Nucleoprotein (NP)

Reactivity: Influenza A Virus

Host: Rabbit

Clonality: Polyclonal

Conjugate: Biotin

Application: ELISA, Western Blotting (WB)

Product Details

Purification: Caprylic Acid Ammonium Sulfate Precipitation purified

Immunogen: Recombinant Influenza A virus Nucleoprotein protein

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C/-80 °C

Target Details

Target: Influenza Nucleoprotein (NP)

Alternative Name: Influenza Nucleoprotein

Target Type: Influenza Protein

Background: Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein\\\\\\\'s nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein\\\\\\\'s nuclear localization signals, targeting the RNP to the nucleus.

UniProt: P03466