HCRTR1 antibody (N-Term)

Catalog No. ABIN2764055

The Rabbit Polyclonal anti-HCRTR1 antibody is suitable to detect HCRTR1 in samples from Human. It has been validated for ELISA.

Quick Overview for HCRTR1 antibody (N-Term) (ABIN2764055)

Target: HCRTR1 (Hypocretin (Orexin) Receptor 1 (HCRTR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HCRTR1 antibody is un-conjugated

Application: ELISA

Product Details anti-HCRTR1 Antibody

Binding Specificity: N-Term

Cross-Reactivity: Human

Characteristics: Ox1r, Hypocretin receptor type 1,As first published in 1998 by Sakurai et al, the initial neuropeptides Orexin A and Orexin B were shown to be important in the regulation of appetite. Continued research now suggests that these peptides also influence a wide range of physiological and behavioral processes such as increased EFG arousal and wakefulness and locomotor activity. In addition to the orexins , two G-protein coupled receptors, designated orexin receptor-1 and orexin receptor-2, have been identified which presumably mediate the signaling events from these neuropeptides1. Recently Orexin Receptors have been found to activate extracellular signal-regulated kinases in CHO cells, namely ERK phosporylation, through Ca2+ influx..2. Further studies seem to indicate a mechanism for orexin receptor mediated cell death and suggest a pathway from GPCRs to apoptosis throughthe MAPK pathways.3

Purification: Antigen Immunoaffiinity Purification

Immunogen: Synthetic peptide made to the N terminal of human Orexin Receptor 1

Isotype: IgG

Application Details

Application Notes: Antibody can be used for Western blotting at Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Buffer: Immunoaffinity antibody povided as solution in phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for HCRTR1

Target: HCRTR1 (Hypocretin (Orexin) Receptor 1 (HCRTR1))

Alternative Name: Orexin Receptor-1

UniProt: O43613

Pathways: Feeding Behaviour