UROD antibody (N-Term)

Catalog No. ABIN2773790

The Rabbit Polyclonal anti-UROD antibody is suitable to detect UROD in samples from Human, Rat, Mouse, Cow, Sheep, Dog, Guinea Pig, Rabbit, Horse, Pig, Saccharomyces cerevisiae and Zebrafish (Danio rerio). It has been validated for WB and IHC.

Quick Overview for UROD antibody (N-Term) (ABIN2773790)

Target: UROD (Uroporphyrinogen Decarboxylase (UROD))

Reactivity: Human, Rat, Mouse, Cow, Sheep, Dog, Guinea Pig, Rabbit, Horse, Pig, Saccharomyces cerevisiae, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UROD antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-UROD Antibody

Binding Specificity: N-Term

Purpose: UROD Antibody - N-terminal region

Sequence: VPGKGPSFPE PLREEQDLER LRDPEVVASE LGYVFQAITL TRQRLAGRVP

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Yeast: 100%, Zebrafish: 83%

Characteristics: This is a rabbit polyclonal antibody against UROD. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human UROD

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8115542

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for UROD

Target: UROD (Uroporphyrinogen Decarboxylase (UROD))

Alternative Name: UROD

Background:

Background Information: UROD is the fifth enzyme of the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.This gene encodes the fifth enzyme of the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.

Gene Name: Uroporphyrinogen decarboxylase

Alternative Symbols: PCT, UPD

Protein Name: Uroporphyrinogen decarboxylase

Molecular Weight: 40kDa

Gene ID: 7389

NCBI Accession: NP_000365

UniProt: P06132