ST14 antibody (C-Term)

Catalog No. ABIN2773910

Cited in 1 publication. The Rabbit Polyclonal anti-ST14 antibody (ABIN2773910) specifically detects ST14 in WB and IHC. The antibody is reactive with Human, Mouse, Rat, Cow, Guinea Pig, Horse, Dog, Pig and Rabbit samples.

Quick Overview for ST14 antibody (C-Term) (ABIN2773910)

Target: ST14 (Suppression of Tumorigenicity 14 (ST14))

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Horse, Dog, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ST14 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-ST14 Antibody

Binding Specificity: C-Term

Purpose: ST14 Antibody - C-terminal region

Sequence: SHVFPAGKAI WVTGWGHTQY GGTGALILQK GEIRVINQTT CENLLPQQIT

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against ST14. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human ST14

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP48056-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-ST14 antibody (ABIN2773910)

Landova Sulcova, Zahradnicek, Dumkova, Dosedelova, Krivanek, Hampl, Kavkova, Zikmund, Gregorovicova, Sedmera, Kaiser, Tucker, Buchtova: "Developmental mechanisms driving complex tooth shape in reptiles." in: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 249, Issue 4, pp. 441-464, (2020) (PubMed).

Target Details for ST14

Target: ST14 (Suppression of Tumorigenicity 14 (ST14))

Alternative Name: ST14

Background:

Background Information: ST14 is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.

Gene Name: Suppression of tumorigenicity 14 (colon carcinoma)

Alternative Symbols: HAI, CAP3, MTSP1, SNC19, ARCI11, MT-SP1, PRSS14, TADG15, TMPRSS14

Protein Name: Suppressor of tumorigenicity 14 protein

Molecular Weight: 95kDa

Gene ID: 6768

UniProt: Q9Y5Y6