CDR2 antibody (N-Term)

Catalog No. ABIN2773981

Product Details anti-CDR2 Antibody

Target: CDR2 (Cerebellar Degeneration-Related Protein 2, 62kDa (CDR2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDR2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Sequence: MLAENLVEEF EMKEDEPWYD HQDLQQDLQL AAELGKTLLD RNTELEDSVQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against CDR2. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CDR2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 454 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CDR2

Target: CDR2 (Cerebellar Degeneration-Related Protein 2, 62kDa (CDR2))

Alternative Name: CDR2 (CDR2 Products)

Synonyms: CDR62 antibody, Yo antibody, cdr2 antibody, MGC69206 antibody, CDR2 antibody, AA617262 antibody, RGD1310578 antibody, cerebellar degeneration related protein 2 antibody, cerebellar degeneration related protein 2 L homeolog antibody, cerebellar degeneration-related 2 antibody, cerebellar degeneration-related protein 2 antibody, cerebellar degeneration related protein 2 like antibody, CDR2 antibody, cdr2 antibody, cdr2.L antibody, Cdr2 antibody, CDR2L antibody, LOC101060399 antibody

Background: Cdr2 normally sequesters c-Myc in the neuronal cytoplasm, thereby down-regulating c-Myc activity, and suggest a mechanism whereby inhibition of cdr2 function by autoantibodies in PCD may contribute to Purkinje neuronal.
Alias Symbols: CDR62, Yo
Protein Interaction Partner: SMARCE1, CEP57L1, KANSL1, CCDC153, C4orf46, TXLNA, ALS2CR11, C1orf216, HAUS1, ANKRD36BP1, TCHP, FAM161A, ENKD1, FAM110A, LENG1, SCNM1, SH2D4A, LIN37, RCOR3, TBC1D22B, WDYHV1, CCHCR1, AMOTL2, FZR1, RSPH14, CHIC2, MRPL28, TMCC2, HDAC4, EIF4E2, TTR, COX5B, T
Protein Size: 454

Molecular Weight: 52 kDa

Gene ID: 1039

NCBI Accession: NM_001802, NP_001793

UniProt: Q01850