SETMAR antibody (C-Term)

Catalog No. ABIN2773983

This Rabbit Polyclonal antibody specifically detects SETMAR in WB. It exhibits reactivity toward Human and Cow.

Quick Overview for SETMAR antibody (C-Term) (ABIN2773983)

Target: SETMAR (SET Domain and Mariner Transposase Fusion Gene (SETMAR))

Reactivity: Human, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SETMAR antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SETMAR Antibody

Binding Specificity: C-Term

Sequence: FLQGKRFHNQ QDAENAFQEF VESQSTDFYA TGINQLISRW QKCVDCNGSY

Predicted Reactivity: Cow: 100%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against SETMAR. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human SETMAR

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SETMAR

Target: SETMAR (SET Domain and Mariner Transposase Fusion Gene (SETMAR))

Alternative Name: SETMAR

Background: This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain.
Protein Interaction Partner: CHEK1, H3F3C, tat, PRPF19, SETMAR, RAD9A, PCNA, TOP2A, XRCC4,
Protein Size: 545

Molecular Weight: 59 kDa

Gene ID: 6419

NCBI Accession: NP_001230652

UniProt: E7EN68

Pathways: Positive Regulation of Response to DNA Damage Stimulus