SETMAR antibody (Internal Region)

Catalog No. ABIN7224234

The Rabbit Polyclonal anti-SETMAR antibody is suitable to detect SETMAR in samples from Human, Mouse and Rat. It has been validated for ELISA, IHC and IF.

Quick Overview for SETMAR antibody (Internal Region) (ABIN7224234)

Target: SETMAR (SET Domain and Mariner Transposase Fusion Gene (SETMAR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SETMAR antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-SETMAR Antibody

Binding Specificity: Internal Region

Purpose: Rabbit Anti-SETMAR Polyclonal Antibody

Specificity: SETMAR Polyclonal Antibody detects endogenous levels of SETMAR protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human SETMAR

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300,ELISA 1:40000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for SETMAR

Target: SETMAR (SET Domain and Mariner Transposase Fusion Gene (SETMAR))

Alternative Name: SETMAR

Background: SETMAR, Histone-lysine N-methyltransferase SETMAR, SET domain and mariner transposase fusion gene-containing protein, HsMar1, MetnaseSETMAR (SET domain and mariner transposase fusion gene) encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. SETMAR exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants.

Gene ID: 6419

UniProt: Q53H47

Pathways: Positive Regulation of Response to DNA Damage Stimulus