CSK antibody (Middle Region)

Catalog No. ABIN2774001

This Rabbit Polyclonal antibody specifically detects CSK in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Cow, Zebrafish (Danio rerio), Dog, Guinea Pig and Horse.

Quick Overview for CSK antibody (Middle Region) (ABIN2774001)

Target: CSK (C-Src tyrosine Kinase (CSK))

Reactivity: Human, Mouse, Rat, Cow, Zebrafish (Danio rerio), Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CSK antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-CSK Antibody

Binding Specificity: Middle Region

Sequence: SEDNVAKVSD FGLTKEASST QDTGKLPVKW TAPEALREKK FSTKSDVWSF

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against CSK. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CSK

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 450 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CSK

Target: CSK (C-Src tyrosine Kinase (CSK))

Alternative Name: CSK

Background: CSK specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site.CSK can also act on the LYN and FYN kinases.
Alias Symbols: MGC117393
Protein Interaction Partner: UBC, EGFR, TNRC6B, PAG1, RGS16, ZAP70, CD247, CD3E, KHDRBS1, TENC1, FRK, ARRB2, ARRB1, AKT1, GRB2, VCP, ID3, FHL2, SRCIN1, ZNF212, G3BP1, UBASH3B, SHC1, CBL, JUN, ELAVL1, Csk, MAPK15, DOK3, PTPN22, PTPN18, SIT1, TLR3, LAIR1, DOK1, PXN, PLD2, PRKACA, DAB2,
Protein Size: 450

Molecular Weight: 51 kDa

Gene ID: 1445

NCBI Accession: NM_004383, NP_004374

UniProt: P41240

Pathways: TCR Signaling, EGFR Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events