USP21 antibody (N-Term)

Catalog No. ABIN2774072

Product Details anti-USP21 Antibody

Target: USP21 (Ubiquitin Specific Peptidase 21 (USP21))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP21 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PLPPRPGPPD ERLKKLELGR GRTSGSRPRG PLRADHGVPL PGSPPPAVAL

Predicted Reactivity: Cow: 86%, Dog: 86%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Usp21. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Mouse Usp21

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 566 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for USP21

Target: USP21 (Ubiquitin Specific Peptidase 21 (USP21))

Alternative Name: Usp21 (USP21 Products)

Synonyms: USP21 antibody, USP16 antibody, USP23 antibody, ESTM28 antibody, Usp16 antibody, Usp23 antibody, W53272 antibody, ubiquitin specific peptidase 21 antibody, USP21 antibody, Usp21 antibody

Background: Usp21 deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Usp21 regulates gene expression via histone H2A deubiquitination. It is also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates.
Alias Symbols: ESTM28, Usp16, Usp23, W53272
Protein Interaction Partner: Eed, TGFBR1, ACVR1,
Protein Size: 566

Molecular Weight: 62 kDa

Gene ID: 30941

NCBI Accession: NM_013919, NP_038947

UniProt: Q9QZL6