DSTYK antibody (Middle Region)

Catalog No. ABIN2774127

Cited in 1 publication. The Rabbit Polyclonal anti-DSTYK antibody (ABIN2774127) specifically detects DSTYK in WB. The antibody is reactive with Human, Rat, Mouse, Cow, Dog, Guinea Pig and Rabbit samples.

Quick Overview for DSTYK antibody (Middle Region) (ABIN2774127)

Target: DSTYK (Dual serine/threonine and tyrosine Protein Kinase (DSTYK))

Reactivity: Human, Rat, Mouse, Cow, Dog, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DSTYK antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DSTYK Antibody

Binding Specificity: Middle Region

Purpose: RIPK5 Antibody - middle region

Sequence: EECWQLMEAC WDGDPLKRPL LGIVQPMLQG IMNRLCKSNS EQPNRGLDDS

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Human: 100%, Mouse: 86%, Rabbit: 85%, Rat: 90%

Characteristics: This is a rabbit polyclonal antibody against RIPK5. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RIPK5

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP55938-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-DSTYK antibody (ABIN2774127)

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

Target Details for DSTYK

Target: DSTYK (Dual serine/threonine and tyrosine Protein Kinase (DSTYK))

Alternative Name: RIPK5

Background:

Background Information: RIPK5 may induce both caspase-dependent apoptosis and caspase-independent cell death.This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. Multiple alternatively spliced transcript variants have been found, but the biological validity of some variants has not been determined.

Gene Name: Dual serine/threonine and tyrosine protein kinase

Alternative Symbols: RIP5, RIPK5, SPG23, CAKUT1, DustyPK, HDCMD38P

Protein Name: Dual serine/threonine and tyrosine protein kinase

Molecular Weight: 100kDa

Gene ID: 25778

NCBI Accession: NP_955749

UniProt: Q6XUX3