RNF216 antibody (N-Term)

Catalog No. ABIN2774202

This Rabbit Polyclonal antibody specifically detects RNF216 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Horse, Dog, Guinea Pig and Rabbit.

Quick Overview for RNF216 antibody (N-Term) (ABIN2774202)

Target: RNF216 (Ring Finger Protein 216 (RNF216))

Reactivity: Human, Mouse, Rat, Cow, Horse, Dog, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF216 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RNF216 Antibody

Binding Specificity: N-Term

Purpose: Rnf216 Antibody - N-terminal region

Sequence: IVNPRLEQKV IILGENGLLF PESEPLEVQN QSSEDSETEL LSNPGEPAAS

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against Rnf216. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of MOUSE Rnf216

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP57824-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for RNF216

Target: RNF216 (Ring Finger Protein 216 (RNF216))

Alternative Name: Rnf216

Background:

Background Information: Rnf216 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. It promotes degradation of TRAF3, TLR4 and TLR9. It contributes to the regulation of antiviral responses. It down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production and promotes TNF and RIP mediated apoptosis.

Gene Name: ring finger protein 216

Alternative Symbols: UIP, UIP83, C86502, TRIAD3, Ubce7i, AI647468, AU019462, Ubce7ip1, 2810055G22Rik, F830018F18Rik

Protein Name: E3 ubiquitin-protein ligase RNF216

Molecular Weight: 93kDa

Gene ID: 108086

UniProt: P58283