GAN antibody (Middle Region)

Catalog No. ABIN2774225

Product Details anti-GAN Antibody

Target: GAN (Gigaxonin (GAN))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Mouse, Cow, Rabbit, Dog, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GAN antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: IYLNDQNLCI PASSSFVYGA VPIGASIYVI GDLDTGTNYD YVREFKRSTG

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against GAN. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GAN

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 597 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GAN

Target: GAN (Gigaxonin (GAN))

Alternative Name: GAN (GAN Products)

Synonyms: MGC81691 antibody, GAN antibody, A330045G18 antibody, gigaxonin antibody, GAN1 antibody, KLHL16 antibody, gigaxonin L homeolog antibody, gigaxonin antibody, giant axonal neuropathy antibody, gan.L antibody, gan antibody, GAN antibody, Gan antibody

Background: This gene encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The encoded protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and degradation of some proteins. Defects in this gene are a cause of giant axonal neuropathy (GAN).
Alias Symbols: FLJ38059, GAN1, KLHL16
Protein Interaction Partner: RELA, HSP90AA1, CUL3, UBA1, TBCB, UBC, ATG16L1, RBX1, MAP1B, SFN,
Protein Size: 597

Molecular Weight: 66 kDa

Gene ID: 8139

NCBI Accession: NM_022041, NP_071324

UniProt: Q9H2C0