Caspase 6 antibody (Middle Region)

Catalog No. ABIN2774243

The Rabbit Polyclonal anti-Caspase 6 antibody has been validated for WB. It is suitable to detect Caspase 6 in samples from Human, Mouse and Pig.

Quick Overview for Caspase 6 antibody (Middle Region) (ABIN2774243)

Target: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Reactivity: Human, Mouse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Caspase 6 Antibody

Binding Specificity: Middle Region

Sequence: QACRGNQHDV PVIPLDVVDN QTEKLDTNIT EVDAASVYTL PAGADFLMCY

Predicted Reactivity: Human: 100%, Mouse: 82%, Pig: 77%

Characteristics: This is a rabbit polyclonal antibody against CASP6. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CASP6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 293 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Caspase 6

Target: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Alternative Name: CASP6

Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms.
Alias Symbols: MCH2
Protein Interaction Partner: CASP6, XIAP, CRYAB, UBC, CASP3, RB1, IKBKG, PRKAB2, SP1, COPS6, SATB1, TAB1, MAPK6, PIN1, UBE4A, NUAK1, UBE4B, CHD3, PSME3, EIF2S1, CFLAR, PPL, NEDD4, SRP72, CASP8, CASP10, TRAF1, PSEN2, SRF, VIM, PRKCZ, MAPT, LMNB1, LMNA, KRT18, HTT, TOP1, DSP, PCYT1A, T
Protein Size: 293

Molecular Weight: 33 kDa

Gene ID: 839

NCBI Accession: NM_001226, NP_001217

UniProt: P55212

Pathways: Apoptosis, Caspase Cascade in Apoptosis