EIF6 antibody (N-Term)

Catalog No. ABIN2774313

This anti-EIF6 antibody is a Rabbit Polyclonal antibody detecting EIF6 in WB. Suitable for Human, Mouse, Rat, Rabbit, Cow, Dog, Guinea Pig, Horse, Sheep, Saccharomyces cerevisiae, Zebrafish (Danio rerio).

Quick Overview for EIF6 antibody (N-Term) (ABIN2774313)

Target: EIF6 (Eukaryotic Translation Initiation Factor 6 (EIF6))

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Guinea Pig, Horse, Sheep, Saccharomyces cerevisiae, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EIF6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-EIF6 Antibody

Binding Specificity: N-Term

Sequence: AVRASFENNC EIGCFAKLTN TYCLVAIGGS ENFYSVFEGE LSDTIPVVHA

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 86%, Yeast: 85%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against EIF6. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 245 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for EIF6

Target: EIF6 (Eukaryotic Translation Initiation Factor 6 (EIF6))

Alternative Name: EIF6

Background: Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits.
Alias Symbols: 2, CAB, EIF3A, ITGB4BP, b, b(2)gcn, gcn, p27BBP, eIF-6, p27(BBP)
Protein Interaction Partner: ZNF622, BCCIP, PPAN, NMD3, GLTSCR2, GTPBP4, POP1, TOP2B, TOP2A, RNF2, CNBP, RARS, PPP5C, PEPD, PAFAH1B2, HSPA9, HSPA1A, HPRT1, EIF4E, DFFA, CFL1, CAPN1, ASNA1, GINS3, BZW2, ABHD14A, TNFAIP8, XRN2, HDAC9, ZBTB26, VCAM1, UBC, ECT2, HNRNPU, FBL, DHX9, APP, R
Protein Size: 245

Molecular Weight: 27 kDa

Gene ID: 3692

NCBI Accession: NM_002212, NP_002203

UniProt: P56537

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly