VPS4B antibody (N-Term)

Catalog No. ABIN2774320

This anti-VPS4B antibody is a Rabbit Polyclonal antibody detecting VPS4B in WB. Suitable for Human, Rat, Dog, Guinea Pig, Horse, Rabbit and Cow.

Quick Overview for VPS4B antibody (N-Term) (ABIN2774320)

Target: VPS4B (vps4b) (Vacuolar Protein Sorting 4 Homolog B (vps4b))

Reactivity: Human, Rat, Dog, Guinea Pig, Horse, Rabbit, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VPS4B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-VPS4B Antibody

Binding Specificity: N-Term

Sequence: EKLKEYLKNK EKKAQKPVKE GQPSPADEKG NDSDGEGESD DPEKKKLQNQ

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Rabbit: 86%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against VPS4B. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 444 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for VPS4B

Target: VPS4B (vps4b) (Vacuolar Protein Sorting 4 Homolog B (vps4b))

Alternative Name: VPS4B

Background: The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18, the gene for the other resides on chromosome 16.
Alias Symbols: MIG1, SKD1, SKD1B, VPS4-2
Protein Interaction Partner: ZFYVE19, CHMP5, UBC, HTRA2, CHMP4A, TTLL12, AHCYL1, SSSCA1, YAP1, UBE4B, PDCD6IP, USP34, VPS26A, USP8, ZPR1, NUP214, TYMS, RAB5B, IGBP1, TTC9C, ZNF585B, UBQLN4, UBXN1, UBQLN1, CUL3, CHMP2A, CHMP1A, ELAVL1, BABAM1, CHMP1B, VPS4A, VPS4, LIP5,
Protein Size: 444

Molecular Weight: 49 kDa

Gene ID: 9525

NCBI Accession: NM_004869, NP_004860

UniProt: O75351

Pathways: Microtubule Dynamics, CXCR4-mediated Signaling Events