Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) (C-Term) antibody

Details for Product No. ABIN2774386
Antigen
Epitope
C-Term
10
4
2
2
2
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rabbit, Rat (Rattus), Zebrafish (Danio rerio)
46
28
27
3
3
3
3
3
2
2
2
2
1
Host
Rabbit
43
3
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
30
14
13
10
5
3
2
2
1
1
1
Options
Blocking Peptide Blocking peptide for this product available: ABIN981738
Sequence DLDSSLANLV GNLGIGNGTT KNDVNWSQPG EKKLTGGSNW QPKVAPTTAW
Predicted Reactivity Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
Characteristics This is a rabbit polyclonal antibody against PICALM. It was validated on Western Blot.
Purification Affinity Purified
Antigen
Alternative Name PICALM (PICALM Antibody Abstract)
Background This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10,11)(p13,q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease.
Alias Symbols: CALM, CLTH, LAP
Protein Interaction Partner: UBC, PELI2, VCAM1, ITGA4, FN1, SIRT1, ILF3, EGFR, EEF1A1, DNM2, CD55, ABCC2, ATP6V1E1, AP2A1, SH3GLB2, FLOT1, HNRNPDL, SEC24D, SEC24C, ATP6V1F, HIP1R, LAMTOR3, ITSN1, EHD2, CASP8, CLTCL1, CASP3, PLCG1, DDIT3, CLTC,
Protein Size: 551
Molecular Weight 60 kDa
Gene ID 8301
NCBI Accession NM_001206947, NP_001193876
UniProt E9PN05
Pathways Synaptic Membrane
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 551 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Image no. 1 for anti-Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) (C-Term) antibody (ABIN2774386) anti-Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) (C-Term) antibody