TPSB2 antibody (Middle Region)

Catalog No. ABIN2774583

Product Details anti-TPSB2 Antibody

Target: TPSB2 (Tryptase beta 2 (TPSB2))

Binding Specificity: Middle Region

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TPSB2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: QALQRVGIVG GQEAPRSKWP WQVSLRVHGP YWMHFCGGSL IHPQWVLTAA

Predicted Reactivity: Human: 100%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against TPSB2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TPSB2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TPSB2

Target: TPSB2 (Tryptase beta 2 (TPSB2))

Alternative Name: TPSB2 (TPSB2 Products)

Synonyms: TPS2 antibody, tryptaseB antibody, tryptaseC antibody, Mcpt6 antibody, tryptase beta 2 (gene/pseudogene) antibody, tryptase beta 2 antibody, TPSB2 antibody, Tpsb2 antibody

Background: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.
Alias Symbols: TPS2, tryptaseB, tryptaseC
Protein Size: 282

Molecular Weight: 31 kDa

Gene ID: 64499

NCBI Accession: NM_003294, NP_003285

UniProt: P20231