EXOC2 antibody (N-Term)

Catalog No. ABIN2774594

This anti-EXOC2 antibody is a Rabbit Polyclonal antibody detecting EXOC2 in WB. Suitable for Mouse, Human, Rat, Cow, Dog, Guinea Pig, Horse and Rabbit.

Quick Overview for EXOC2 antibody (N-Term) (ABIN2774594)

Target: EXOC2 (Exocyst Complex Component 2 (EXOC2))

Reactivity: Mouse, Human, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EXOC2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-EXOC2 Antibody

Binding Specificity: N-Term

Sequence: MLDLDNDTRP SVLGHLSQTA SLKRGSSFQS GRDDTWRYKT PHRVAFVEKL

Predicted Reactivity: Cow: 85%, Dog: 100%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against EXOC2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human EXOC2

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for EXOC2

Target: EXOC2 (Exocyst Complex Component 2 (EXOC2))

Alternative Name: EXOC2

Background: The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants.
Alias Symbols: SEC5, Sec5p, SEC5L1
Protein Size: 519

Molecular Weight: 57 kDa

Gene ID: 55770

NCBI Accession: NM_018303, NP_060773

UniProt: Q96KP1

Pathways: Peptide Hormone Metabolism, Regulation of Actin Filament Polymerization, Synaptic Vesicle Exocytosis