Klotho antibody (N-Term)

Catalog No. ABIN2774619

This Rabbit Polyclonal antibody specifically detects Klotho in WB. It exhibits reactivity toward Human.

Quick Overview for Klotho antibody (N-Term) (ABIN2774619)

Target: Klotho (KL)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Klotho antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Klotho Antibody

Binding Specificity: N-Term

Sequence: FPDGFLWAVG SAAYQTEGGW QQHGKGASIW DTFTHHPLAP PGDSRNASLP

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against KL. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the n terminal region of human KL

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 549 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Klotho

Target: Klotho (KL)

Alternative Name: KL

Background: This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (
Alias Symbols: -
Protein Interaction Partner: IGF1R,
Protein Size: 549

Molecular Weight: 60 kDa

Gene ID: 9365

NCBI Accession: NM_033549

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hormone Activity, Growth Factor Binding