ADAR antibody (C-Term)

Catalog No. ABIN501586

This Rabbit Polyclonal antibody specifically detects ADAR in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Guinea Pig, Horse and Rabbit.It has been mentioned in 1 publication

Quick Overview for ADAR antibody (C-Term) (ABIN501586)

Target: ADAR (Adenosine Deaminase, RNA-Specific (ADAR))

Reactivity: Human, Mouse, Rat, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADAR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-ADAR Antibody

Binding Specificity: C-Term

Purpose: ADAR Antibody - C-terminal region

Sequence: RMGFTEVTPV TGASLRRTML LLSRSPEAQP KTLPLTGSTF HDQIAMLSHR

Predicted Reactivity: Guinea Pig: 92%, Horse: 92%, Human: 92%, Mouse: 91%, Rabbit: 92%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against ADAR. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human ADAR

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP36712-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-ADAR antibody (ABIN501586)

Pan, Ye, Franco, Li, Yu, Zou, Zhang, Jiao, Lin: "Insulin resistance and depressive symptoms in middle-aged and elderly Chinese: findings from the Nutrition and Health of Aging Population in China Study." in: Journal of affective disorders, Vol. 109, Issue 1-2, pp. 75-82, (2008) (PubMed).

Target Details for ADAR

Target: ADAR (Adenosine Deaminase, RNA-Specific (ADAR))

Alternative Name: ADAR

Background:

Background Information: ADAR is responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene Name: Adenosine deaminase, RNA-specific

Alternative Symbols: DSH, AGS6, G1P1, IFI4, P136, ADAR1, DRADA, DSRAD, IFI-4, K88DSRBP

Protein Name: Double-stranded RNA-specific adenosine deaminase

Molecular Weight: 136kDa

Gene ID: 103

NCBI Accession: NP_001102

UniProt: P55265

Pathways: Protein targeting to Nucleus