FBXL2 antibody (N-Term)

Catalog No. ABIN2774686

Product Details anti-FBXL2 Antibody

Target: FBXL2 (F-Box and Leucine-Rich Repeat Protein 2 (FBXL2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Zebrafish (Danio rerio), Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXL2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: NISKRCGGFL RKLSLRGCIG VGDSSLKTFA QNCRNIEHLN LNGCTKITDS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 77%, Rat: 100%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against FBXL2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FBXL2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 423 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FBXL2

Target: FBXL2 (F-Box and Leucine-Rich Repeat Protein 2 (FBXL2))

Alternative Name: FBXL2 (FBXL2 Products)

Synonyms: FBL2 antibody, FBL3 antibody, 2810423A21Rik antibody, Fbl3 antibody, RGD1562243 antibody, fbxl20 antibody, sb:cb783 antibody, zgc:73374 antibody, Fbl2 antibody, Fbxl2 antibody, F-box and leucine rich repeat protein 2 antibody, F-box and leucine-rich repeat protein 2 antibody, F-box and leucine-rich repeat protein 20 antibody, FBXL2 antibody, Fbxl2 antibody, fbxl2 antibody, Fbxl20 antibody

Background: FBXL2 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. FBXL2 belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats.This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats.
Alias Symbols: DKFZP564P0622, FBL2, FBL3
Protein Interaction Partner: SKP1, RABGGTB, PIK3R1, CDC34, CUL2, UBE2D3, PTPN13, PIK3R2, HSP90AA1, AURKB, HCVgp1, CCND2, CUL1, APP, COL7A1,
Protein Size: 423

Molecular Weight: 47 kDa

Gene ID: 25827

NCBI Accession: NM_012157, NP_036289

UniProt: Q9UKC9