FBXL3 antibody (C-Term)

Catalog No. ABIN2774688

The Rabbit Polyclonal anti-FBXL3 antibody has been validated for WB. It is suitable to detect FBXL3 in samples from Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit, Sheep and Zebrafish (Danio rerio).

Quick Overview for FBXL3 antibody (C-Term) (ABIN2774688)

Target: FBXL3 (F-Box and Leucine-Rich Repeat Protein 3 (FBXL3))

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXL3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FBXL3 Antibody

Binding Specificity: C-Term

Sequence: ELLLALSSEK HVRLEHLRID VVSENPGQTH FHTIQKSSWD AFIKHSPKVN

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against Fbxl3. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 428 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FBXL3

Target: FBXL3 (F-Box and Leucine-Rich Repeat Protein 3 (FBXL3))

Alternative Name: Fbxl3

Background: Fbxl3 is a substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex involved in circadian clock function. The SCF(FBXL3) complex acts by mediating ubiquitination and subsequent degradation of CRY1 and CRY2. Recruiter of target protein that may recognize and bind to some phosphorylated proteins and promotes their ubiquitination and degradation.
Alias Symbols: AU041772, AW212966, FBK, Fbl3a, Fbxl3a, Ovtm
Protein Interaction Partner: Skp1a, Cry2, Cry1,
Protein Size: 428

Molecular Weight: 49 kDa

Gene ID: 50789

NCBI Accession: NM_015822, NP_056637

UniProt: Q8C4V4

Pathways: Photoperiodism