ADRB1 antibody (Middle Region)

Catalog No. ABIN2774823

This Rabbit Polyclonal antibody specifically detects ADRB1 in WB. It exhibits reactivity toward Human, Rat, Mouse, Dog, Rabbit, Pig and Guinea Pig. It has been mentioned in 2+ publications

Quick Overview for ADRB1 antibody (Middle Region) (ABIN2774823)

Target: ADRB1 (Adrenergic, beta-1-, Receptor (ADRB1))

Reactivity: Human, Rat, Mouse, Dog, Rabbit, Pig, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADRB1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ADRB1 Antibody

Binding Specificity: Middle Region

Purpose: ADRB1 antibody - middle region

Sequence: CTVWAISALV SFLPILMHWW RAESDEARRC YNDPKCCDFV TNRAYAIASS

Predicted Reactivity: Dog: 87%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against ADRB1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ADRB1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP36551-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-ADRB1 antibody (ABIN2774823)

Wei, Shen, Song, Qiu, Luo: "Propranolol sensitizes thyroid cancer cells to cytotoxic effect of vemurafenib." in: Oncology reports, Vol. 36, Issue 3, pp. 1576-84, (2016) (PubMed).

Tsai, Lee, Chen, Kao, Lu, Lin, Chen, Chen: "Testosterone replacement increases aged pulmonary vein and left atrium arrhythmogenesis with enhanced adrenergic activity." in: International journal of cardiology, Vol. 176, Issue 1, pp. 110-8, (2014) (PubMed).

Target Details for ADRB1

Target: ADRB1 (Adrenergic, beta-1-, Receptor (ADRB1))

Alternative Name: ADRB1

Background:

Background Information: The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in ADRB1 gene have been shown to affect the resting heart rate and can be involved in heart failure.The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Adrenergic, beta-1-, receptor

Alternative Symbols: RHR, B1AR, FNSS2, ADRB1R, BETA1AR

Protein Name: Beta-1 adrenergic receptor

Molecular Weight: 51 kDa

Gene ID: 153

NCBI Accession: NP_000675

UniProt: P08588

Pathways: cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Brown Fat Cell Differentiation