GJB4 antibody (Middle Region)

Catalog No. ABIN2774873

The Rabbit Polyclonal anti-GJB4 antibody is suitable to detect GJB4 in samples from Human, Mouse, Rat, Horse, Cow and Dog. It has been validated for WB.

Quick Overview for GJB4 antibody (Middle Region) (ABIN2774873)

Target: GJB4 (Gap Junction Protein, beta 4, 30.3kDa (GJB4))

Reactivity: Human, Mouse, Rat, Horse, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GJB4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GJB4 Antibody

Binding Specificity: Middle Region

Purpose: GJB4 Antibody - middle region

Sequence: CPSLLVVMHV AYREERERKH HLKHGPNAPS LYDNLSKKRG GLWWTYLLSL

Predicted Reactivity: Cow: 92%, Dog: 92%, Horse: 100%, Human: 100%, Mouse: 86%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against GJB4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GJB4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8101327

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for GJB4

Target: GJB4 (Gap Junction Protein, beta 4, 30.3kDa (GJB4))

Alternative Name: GJB4

Background:

Background Information: Connexins are homologous four-transmembrane-domain proteins and major components of gap junctions. The GJB4 gene encodes connexin 30.3 (Cx30.3) A mutation in connexin 30.3 is causally involved in erythrokeratodermia variabilis (EKV), a mostly autosomal dominant disorder of keratinization.

Gene Name: Gap junction protein, beta 4, 30.3 kDa

Alternative Symbols: EKV, EKVP2, CX30.3

Protein Name: Gap junction beta-4 protein

Molecular Weight: 29kDa

Gene ID: 127534

NCBI Accession: NP_694944

UniProt: Q9NTQ9