Klotho antibody (N-Term)

Catalog No. ABIN2774900

This anti-Klotho antibody is a Rabbit Polyclonal antibody detecting Klotho in WB. Suitable for Mouse, Human, Rat, Rabbit, Horse, Cow and Pig.

Quick Overview for Klotho antibody (N-Term) (ABIN2774900)

Target: Klotho (KL)

Reactivity: Mouse, Human, Rat, Rabbit, Horse, Cow, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Klotho antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Klotho Antibody

Binding Specificity: N-Term

Sequence: GAAPSDSPIV VAPSGAPSPP LSSTGDVASD SYNNVYRDTE GLRELGVTHY

Predicted Reactivity: Cow: 93%, Horse: 93%, Human: 100%, Mouse: 92%, Pig: 91%, Rabbit: 92%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against Kl. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1014 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Klotho

Target: Klotho (KL)

Alternative Name: Kl

Background: Kl may have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 241 and 874, suggesting it may be inactive as a glycosidase in vivo. It may be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1.
Alias Symbols: alpha-kl
Protein Interaction Partner: Trpv5, Fgfr4, Fgfr3, Fgfr2, Fgfr1,
Protein Size: 1014

Molecular Weight: 116 kDa

Gene ID: 16591

NCBI Accession: NM_013823, NP_038851

UniProt: O35082

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hormone Activity, Growth Factor Binding