DUX4 antibody (N-Term)
Quick Overview for DUX4 antibody (N-Term) (ABIN2775040)
Target
See all DUX4 AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- N-Term
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Sequence
- TRGAEGTLGG RQGGREAGRN GGRDRATQGL GAGPREPGTD GGRKAGRKSG
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Predicted Reactivity
- Human: 100%
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Characteristics
- This is a rabbit polyclonal antibody against DUX4. It was validated on Western Blot.
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Purification
- Affinity Purified
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Immunogen
- The immunogen is a synthetic peptide directed towards the N-terminal region of human DUX4
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handling Advice
- Avoid repeat freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- DUX4 (Double Homeobox 4 (DUX4))
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Alternative Name
- DUX4
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Background
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This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length, a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes, the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1, GeneID 5307). Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). Alternative splicing results in multiple transcript variants.
Alias Symbols: DUX4L
Protein Size: 853 -
Molecular Weight
- 93 kDa
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Gene ID
- 100288687
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NCBI Accession
- NM_001293798, NP_001280727
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UniProt
- Q9UBX2
Target
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