DUX4 antibody (N-Term)

Catalog No. ABIN2775040

The Rabbit Polyclonal anti-DUX4 antibody (ABIN2775040) specifically detects DUX4 in WB. The antibody is reactive with Human samples.

Quick Overview for DUX4 antibody (N-Term) (ABIN2775040)

Target: DUX4 (Double Homeobox 4 (DUX4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DUX4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DUX4 Antibody

Binding Specificity: N-Term

Purpose: DUX4 Antibody - N-terminal region

Sequence: TRGAEGTLGG RQGGREAGRN GGRDRATQGL GAGPREPGTD GGRKAGRKSG

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against DUX4. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human DUX4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP36096-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for DUX4

Target: DUX4 (Double Homeobox 4 (DUX4))

Alternative Name: DUX4

Background:

Background Information: This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length, a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes, the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1, GeneID 5307). Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). Alternative splicing results in multiple transcript variants.

Gene Name: double homeobox 4

Alternative Symbols: DUX4L

Protein Name: double homeobox protein 4

Molecular Weight: 93kDa

Gene ID: 100288687

NCBI Accession: NP_001280727

UniProt: Q9UBX2