CBLL2 (N-Term) antibody

Catalog No. ABIN2775102

This Rabbit Polyclonal antibody specifically detects CBLL2 in WB. It exhibits reactivity toward Human. It has been mentioned in 2+ publications

Quick Overview for CBLL2 (N-Term) antibody (ABIN2775102)

Target: CBLL2

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Product Details

Binding Specificity: N-Term

Purpose: CBLL2 Antibody - N-terminal region

Sequence: MNKMPAGEQE CEYNKEGKYY SKGVKLVRKK KKIPGYRWGD IKINIIGEKD

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against ZNF645. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ZNF645

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP36191-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References

Bai, Liu, Zhang, Su, Tao, Yang, Ma, Zhang: "Promoter demethylation mediates the expression of ZNF645, a novel cancer/testis gene." in: BMB reports, Vol. 43, Issue 6, pp. 400-6, (2010) (PubMed).

Liu, Bai, Zhang, Su, Tao, Yang, Ma, Zhang: "Human RING finger protein ZNF645 is a novel testis-specific E3 ubiquitin ligase." in: Asian journal of andrology, Vol. 12, Issue 5, pp. 658-66, (2010) (PubMed).

Target Details

Target: CBLL2

Background:

Background Information: This gene encodes a member of the zinc finger domain-containing protein family. This family member contains both a RING-type and a C2H2-type of zinc finger domain, and it may function as an E3 ubiquitin-protein ligase. Protein localization suggests a role in human sperm production and quality control.

Gene Name: Cbl proto-oncogene like 2

Alternative Symbols: CT138, HAKAIL, ZNF645

Protein Name: E3 ubiquitin-protein ligase CBLL2

Molecular Weight: 49kDa

Gene ID: 158506

NCBI Accession: NP_689790

UniProt: Q8N7E2