INTS6 antibody (C-Term)

Catalog No. ABIN2775213

This Rabbit Polyclonal antibody specifically detects INTS6 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Horse, Pig, Rabbit and Dog.

Quick Overview for INTS6 antibody (C-Term) (ABIN2775213)

Target: INTS6 (Integrator Complex Subunit 6 (INTS6))

Reactivity: Human, Mouse, Rat, Cow, Horse, Pig, Rabbit, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INTS6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-INTS6 Antibody

Binding Specificity: C-Term

Sequence: GFLENHEEPR DKEQCAEENI PASSLNKGKK LMHCRSHEEV NTELKAQIMK

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against INTS6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human INTS6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 874 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for INTS6

Target: INTS6 (Integrator Complex Subunit 6 (INTS6))

Alternative Name: INTS6

Background: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. INTS6 is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene.
Alias Symbols: DBI-1, DDX26, DDX26A, DICE1, DKFZP434B105, HDB, INT6, Notchl2
Protein Interaction Partner: RPA3, RPA2, RPA1, BMI1, UBC, MCM7, INTS10, CTDP1, SHFM1, DDX26B, NAIF1, INTS4, VWA9, INTS5, NABP2, C7orf26, INTS3, ZNF687, INTS2, INTS12, INTS9, ASUN, INTS8, CPSF3L, INTS6, INTS1, INTS7, ZMYND8, ZNF592, PPP2R1B, PPP2R1A, PPP2CB, PPP2CA, PPP1CB, POLR2L, PO
Protein Size: 874

Molecular Weight: 99 kDa

Gene ID: 26512

NCBI Accession: NM_001039937, NP_001035026

UniProt: A8MV98