DHX58 antibody (N-Term)

Catalog No. ABIN2775259

This Rabbit Polyclonal antibody specifically detects DHX58 in WB. It exhibits reactivity toward Human, Rat, Mouse, Guinea Pig, Horse, Cow, Dog and Rabbit.

Quick Overview for DHX58 antibody (N-Term) (ABIN2775259)

Target: DHX58 (DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))

Reactivity: Human, Rat, Mouse, Guinea Pig, Horse, Cow, Dog, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DHX58 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DHX58 Antibody

Binding Specificity: N-Term

Sequence: AYVAKRHLET VDGAKVVVLV NRVHLVTQHG EEFRRMLDGR WTVTTLSGDM

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 91%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against DHX58. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DHX58

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 678 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DHX58

Target: DHX58 (DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))

Alternative Name: DHX58

Background: DHX58 is the negative regulator of host innate immune defense against viruses. The repressor domain of DHX58 interacts with DDX58 and negatively regulates DDX58-mediated signaling. Binds dsRNA produced during viral replication, in particuliar HCV RNA. Bin
Alias Symbols: D11LGP2, D11lgp2e, LGP2
Protein Interaction Partner: USP21, APP, UBD, NKRF, CDKN2AIP, AGO2, STAU2, DICER1, DHX30, XRN2, STAU1, EIF2AK2, EIF6, AP2B1,
Protein Size: 678

Molecular Weight: 76 kDa

Gene ID: 79132

NCBI Accession: NM_024119, NP_077024

UniProt: Q96C10