HAAO antibody (3-hydroxyanthranilate 3,4-Dioxygenase) (N-Term)

Details for Product anti-HAAO Antibody No. ABIN2775371
Target
Binding Specificity
N-Term
6
4
2
1
1
1
1
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Saccharomyces cerevisiae, Zebrafish (Danio rerio)
33
24
23
1
1
1
1
1
Host
Rabbit
33
2
Clonality
Polyclonal
Conjugate
This HAAO antibody is un-conjugated
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
17
14
13
9
5
1
1
1
1
Options
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human HAAO
Blocking Peptide Blocking peptide for this product available: ABIN977833
Sequence HRDVVIRQGE IFLLPARVPH SPQRFANTVG LVVERRRLET ELDGLRYYVG
Predicted Reactivity Cow: 93%, Dog: 86%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 79%, Zebrafish: 86%
Characteristics This is a rabbit polyclonal antibody against HAAO. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Target
Alternative Name HAAO (HAAO Antibody Abstract)
Background 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.
Alias Symbols: 3-HAO, HAO
Protein Interaction Partner: GAD1, BAG3, TERF2IP, POT1, ARHGDIA,
Protein Size: 286
Molecular Weight 32 kDa
Gene ID 23498
NCBI Accession NM_012205, NP_036337
UniProt P46952
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 286 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Images
Image no. 1 for anti-3-hydroxyanthranilate 3,4-Dioxygenase (HAAO) (N-Term) antibody (ABIN2775371) WB Suggested Anti-HAAO Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Posi...