CEMIP2 (Middle Region) antibody

Catalog No. ABIN2775385

This Rabbit Polyclonal antibody specifically detects CEMIP2 in WB. It exhibits reactivity toward Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat and Guinea Pig.It has been mentioned in 1 publication

Quick Overview for CEMIP2 (Middle Region) antibody (ABIN2775385)

Target: CEMIP2

Reactivity: Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Application: Western Blotting (WB)

Product Details

Binding Specificity: Middle Region

Purpose: CEMIP2 Antibody - middle region

Sequence: MLTGLCQGCG TRQVVFTSDP HKSYLPVQFQ SPDKAETQRG DPSVISVNGT

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against TMEM2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TMEM2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP42382-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References

Zhu, Xie, Li, Huang, Zhao, Hu, Wang, Gu, Gao, Peng: "TMEM2 inhibits hepatitis B virus infection in HepG2 and HepG2.2.15 cells by activating the JAK-STAT signaling pathway." in: Cell death & disease, Vol. 7, Issue 6, pp. e2239, (2016) (PubMed).

Target Details

Target: CEMIP2

Background:

Background Information: This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss.

Gene Name: cell migration inducing hyaluronidase 2

Alternative Symbols: TMEM2

Protein Name: cell surface hyaluronidase

Molecular Weight: 154 kDa

Gene ID: 23670

NCBI Accession: NP_037522

UniProt: Q9UHN6