DKK4 antibody (C-Term)

Catalog No. ABIN2775398

The Rabbit Polyclonal anti-DKK4 antibody (ABIN2775398) specifically detects DKK4 in WB. The antibody is reactive with Human, Mouse, Guinea Pig, Rat, Dog, Horse and Rabbit samples.

Quick Overview for DKK4 antibody (C-Term) (ABIN2775398)

Target: DKK4 (Dickkopf Homolog 4 (Xenopus Laevis) (DKK4))

Reactivity: Human, Mouse, Guinea Pig, Rat, Dog, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DKK4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DKK4 Antibody

Binding Specificity: C-Term

Purpose: Dkk4 Antibody - C-terminal region

Sequence: RTSDCGPGLC CARHFWTKIC KPVLREGQVC SRRGHKDTAQ APEIFQRCDC

Predicted Reactivity: Dog: 93%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 79%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Dkk4. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP42406-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for DKK4

Target: DKK4 (Dickkopf Homolog 4 (Xenopus Laevis) (DKK4))

Alternative Name: Dkk4

Background:

Background Information: Dkk4 antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Gene Name: Dickkopf homolog 4 (Xenopus laevis)

Alternative Symbols: Dkk-4

Protein Name: Dickkopf-related protein 4

Molecular Weight: 24kDa

Gene ID: 234130

NCBI Accession: NP_663567

UniProt: Q8VEJ3

Pathways: WNT Signaling