ESRP2 antibody (C-Term)

Catalog No. ABIN2775446

The Rabbit Polyclonal anti-ESRP2 antibody (ABIN2775446) specifically detects ESRP2 in WB. The antibody is reactive with Human, Mouse, Rat, Dog, Rabbit, Cow, Guinea Pig, Horse and Zebrafish (Danio rerio) samples.

Quick Overview for ESRP2 antibody (C-Term) (ABIN2775446)

Target: ESRP2 (Epithelial Splicing Regulatory Protein 2 (ESRP2))

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Cow, Guinea Pig, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ESRP2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ESRP2 Antibody

Binding Specificity: C-Term

Purpose: Esrp2 Antibody - C-terminal region

Sequence: LLPAARVPAA ATPLAYYPGP ATQLYMNYTA YYPSPPVSPT TVGYLTTPPT

Predicted Reactivity: Cow: 100%, Dog: 92%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against Esrp2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP42490-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for ESRP2

Target: ESRP2 (Epithelial Splicing Regulatory Protein 2 (ESRP2))

Alternative Name: Esrp2

Background:

Background Information: Esrp2 is an mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. It specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. It also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). It acts by directly binding specific sequences in mRNAs and binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.

Gene Name: Epithelial splicing regulatory protein 2

Alternative Symbols: Rbm35, Rbm35b, 9530027K23Rik

Protein Name: Epithelial splicing regulatory protein 2

Molecular Weight: 77kDa

Gene ID: 77411

NCBI Accession: NP_789808

UniProt: Q8K0G8