HDAC3 antibody (C-Term)

Catalog No. ABIN2775575

The Rabbit Polyclonal anti-HDAC3 antibody (ABIN2775575) specifically detects HDAC3 in WB. The antibody is reactive with Human, Mouse, Rat, Dog, Cow, Rabbit, Guinea Pig, Horse, Saccharomyces cerevisiae and Zebrafish (Danio rerio) samples.

Quick Overview for HDAC3 antibody (C-Term) (ABIN2775575)

Target: HDAC3 (Histone Deacetylase 3 (HDAC3))

Reactivity: Human, Mouse, Rat, Dog, Cow, Rabbit, Guinea Pig, Horse, Saccharomyces cerevisiae, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HDAC3 Antibody

Binding Specificity: C-Term

Purpose: Hdac3 Antibody - C-terminal region

Sequence: DVPADLLTYD RTDEADAEER GPEENYSRPE APNEFYDGDH DNDKESDVEI

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 83%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against Hdac3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Rat

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP42786-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for HDAC3

Target: HDAC3 (Histone Deacetylase 3 (HDAC3))

Alternative Name: Hdac3

Background:

Background Information: Hdac3 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.Hdac3 is required to repress transcription of the POU1F1 transcription factor. Hdac3 acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.

Gene Name: Histone deacetylase 3

Alternative Symbols: Hdac3

Protein Name: Histone deacetylase 3

Molecular Weight: 49kDa

Gene ID: 84578

NCBI Accession: NP_445900

UniProt: Q6P6W3

Pathways: Neurotrophin Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development